This research report by the Learning Policy Institute highlights the need to redesign high schools from places of factory models to evidence-based models aligned based on the guiding principles of the science of learning and development. To prepare students for today’s challenges, the report proposes 10 features to redesign high schools: (1) positive developmental relationships; (2) safe, inclusive school climate; (3) culturally responsive and sustaining teaching; (4) deeper learning curriculum; (5) student-centered pedagogy; (6) authentic assessment; (7) well-prepared and well-supported teachers; (8) authentic family engagement; (9) community connections and integrated student supports; and (10) shared decision-making and leadership. These features aim to support equitable and empowering educational experiences for every child by moving high schools out of outdated mindsets such as “getting through the book.” Teacher and leader preparation programs can use this report to inform coursework, field experiences, and partnerships that prepare educators to design and lead learning environments aligned with these principles.