This research report from the Community for Advancing Discovery Research in Education examines the opportunities and challenges of Generative AI (GenAI) in STEM teaching. It explores GenAI’s potential effects on equity and inclusion, curriculum design, pedagogy, assessment, and teacher development. The authors emphasize a human-centered approach, where AI supports rather than replaces educators, and highlight the importance of involving teachers and communities in co-designing these tools. The report recommends investing in diverse training and ongoing professional development to build teacher GenAI literacy through preparation programs and in-service support. It also addresses risks such as bias, misinformation, and data privacy, underscoring the need for careful and ethical integration into STEM education.