This case study research and brief from researchers with the College of Education at the University of South Carolina and the University of California, Los Angeles Center for Community Schooling highlights the need for policies that enable teachers to create learning experiences that support students’ holistic well-being and prepare them for the rapidly changing world. Through two case studies of Surrey Schools and the Anaheim Union High School District the authors focus on identifying conditions in which teachers can ensure that all young people can develop into successful and thriving adults. The research documents how student-led learning and leadership by teachers have become linked. It shows how two districts began their work of transforming teaching and learning first by shifting to viewing students as change agents and then by building a system of leading teachers to pursue that vision.