This practice guide from National Girls Collaborative Project offers online and hybrid lessons and activities to help guide science, technology, engineering, and mathematics (STEM) educators in fostering girls’ positive STEM identities. The research-based learning experiences featured in the guide stem from a National Science Foundation–funded project, BRITE Girls Online STEM Practices: Building Relevance and Identity to Transform Experiences. This project includes three major components: (1) community building, (2) engagement with diverse women in STEM role models, and (3) hands-on activities. These components are woven throughout the Brite Project’s creative STEM practices, such as discussing girls’ lived experiences and interests, challenging gendered stereotypical perceptions of STEM professionals, and creating graphic novels and comic books. This guide offers various ways for girls in STEM to build their confidence and sense of belonging in the field.