This guide, published by the Center for the Advancement of Teaching Excellence at the University of Illinois-Chicago, examines the potential and drawbacks of AI writing tools in education. It explores how to approach AI writing tools in the classroom, including lesson design strategies to reduce the risk of students’ overreliance or misuse of AI writing tools. Further, the guide offers instructional activities and opportunities for generative AI to support writing assignments, referencing evidence-based research studies. An example includes a ChatGPT Reflection and Revision Assignment in which students critically reflect on the output of a ChatGPT prompt, then revise the content to address any inaccuracies and biases. Lastly, the guide provides a helpful overview of AI prompt engineering for educators looking to use GenAI as an instructional tool, such as examples of clear instructions and classroom contextual information within prompts. Overall, this guide serves as a resource that educators may use to generate ideas for AI-integrated activities that are grounded in ethical and equitable principles.